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Workshop European Multidisciplinary Scientific Day

Il prossimo 19 aprile saremo presenti al workshop European Multidisciplinary Scientific Day (E.M.S.D.) presso il dipartimento di Chimica e Chimica Industriale in via moruzzi,13 (Pisa ) con l'intervento di Gianpiero Garau .


"Rose" e "Loto" due immagini di Valerio Voliani scelte nell'ambito del Google Lunar Xprize

Il nostro ricecatore Valerio Voliani lascerà una traccia umana sulla Luna per i prossimi 5 milioni di anni!

Le sue due “opere d’arte”,  le immagini che ritraggono nanomateriali da lui stesso raccolte con un microscopio a scansione elettronica e colorate, saranno inserite in una capsula che sarà spedita e depositata alla fine dell’anno sul nostro pianeta satellite, insieme ad altri 300 prodotti di artisti provenienti da tutto il mondo (poesie, suoni, melodie e altre “oggetti”). Le immagini sono state selezionate dalla Carnegie Mellon University e inserite nel concorso Google Lunar Xprize.


How fat foods affect appetite and mood

Garau front Cover from ACS Journal

To promote the absorption of dietary fats during digestion, our body produces a series of natural detergent molecules, named bile acids. Circulating bile acids function also as hormones regulating specific cell receptors. Gianpiero Garau’s group has unveiled that one of these bile acid-targets is the membrane enzyme NAPE-PLD, which generates key lipid signaling molecules that enhance appetite and pleasure, and contemporarily reduce stress and pain. As a result, our wellbeing increases.


Front Cover of PPSC Journal for A nano “Passion Fruit”

Voliani front Cover from PPSC Journal

One of the main concern about the clinical translation of inorganic nanoparticles is related to the accumulation of metals in organisms.

Valerio Voliani and co-workers have introduced the passion fruit-like nano-architectures; silica nanocapsules comprising ultrasmall metal nanoparticles that degrade to kidney-clearable building blocks after their therapeutic or diagnostic action. Moreover, they have demonstrated their application as carriers for cisplatin prodrug. Such an approach is promising to engineer theranostics able to fill the gap between inorganic nanomaterials and oncology.


The mechanism of peptide-based direct plasma membrane translocation finally unveiled at the CNI

Peptides that translocate spontaneously across cell membranes could transform the field of drug delivery by enabling the transport of otherwise membrane-impermeant molecules into cells. In this regard, a 9-aminoacid-long motif (representative sequence: PLIYLRLLR, named here Translocating Motif 9, TM9) that spontaneously translocates across membranes while carrying a polar dye was recently identified by high-throughput screening, and proposed as the precursor sequence for a new generation of drug-delivery vectors. This important topic was approached at the CNI@NEST, in strict collaboration with Scuola Normale Superiore, by a multi-disciplinary team of chemists, physicists, and biologists, guided by Dr. Francesco Cardarelli (CNI@NEST).


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