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How fat foods affect appetite and mood

Garau front Cover from ACS Journal

To promote the absorption of dietary fats during digestion, our body produces a series of natural detergent molecules, named bile acids. Circulating bile acids function also as hormones regulating specific cell receptors. Gianpiero Garau’s group has unveiled that one of these bile acid-targets is the membrane enzyme NAPE-PLD, which generates key lipid signaling molecules that enhance appetite and pleasure, and contemporarily reduce stress and pain. As a result, our wellbeing increases.

This process might be at the base of our food choices, with relevant therapeutic perspectives for the treatment of metabolic and eating disorders, including obesity, bulimia and anorexia. The journal cover of (ACS) Chemical Biology highlights this important discovery.

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