Giovanni Signore's foto

Giovanni Signore

Senior Post Doc

IIT@NEST

Address Piazza san Silvestro,12
City Pisa
ZIP Code 56127
Country Italy
Phone +39 050 509699
IM Address giovannisignore1978 (Skype)

Bio

Education:
2007: PhD in Chemical Sciences University of Pisa, Pisa – Italy
2003: M.Sc. in Industrial Chemistry (Italian Laurea Degree) (110/110 cum laude) University of Pisa, Pisa - Italy

Research interests:

•Synthesis of photocleavable molecules for delivery in living cells.

•Design and enigineering of fluorescent probes (organic dyes or fluorescent proteins) for in vivo studies with single event/single molecule resolution.
•Detection of binding events using fluorescent solvatochromic biosensors.

Research Activity:

• 1st October 2009 to present: IIT Post-Doctoral Fellow at IIT@NEST- Center for Nanotechnology Innovation, Nanomedicine division. Project: development of fluorescent biosensors based on solvatochromic probes for in vivo imaging.

• 1st September 2008- 31th August 2009: Post-doctoral Fellow at NEST-CNR-INFM-Scuola Normale Superiore. Project title: "Intracellular probes of proteins in native state based on fluorescent solvatochromic dyes".
• 1st July 2007-2nd June 2008: Post-Doctoral Fellow at Scuola Normale Superiore. Project title: "Synthesis and characterization of new fluorescent biomarkers".
• 9th September 2006-16th March 2007: internship in the Process Research Laboratory at Boehringer Ingelheim Pharma, Biberach a.d. Riss, DE. Total synthesis of process impurities, development of synthetic sequences directed towards industrial scale-up.

Other Publications

 

  1. Lorenzo Albertazzi; Marco Brondi; Giovanni Pavan; Sebatian Sulis Sato; Giovanni Signore; Barbara Storti; Gian michele Ratto; Fabio Beltram "Dendrimer-based Fluorescent Indicators: In Vitro and In Vivo Applications" PLoS ONE 2011 accepted
  2. Valerio Voliani, Fernanda Ricci, Giovanni Signore, Riccardo Nifosì, Stefano Luin, Fabio Beltram, "Multiphoton Molecular Photorelease in Click-Chemistry-Functionalized Gold Nanoparticles" Small 2011 doi:10.1002/smll.201101753

  3. Gerardo Abbandonato, Giovanni Signore, Riccardo Nifosì, Valerio Voliani, Ranieri Bizzarri and Fabio Beltram, "Cis–trans photoisomerization properties of GFP chromophore analogs" Eur. Biophys. J. 2011, 40, 1205-1214

  4. Signore Giovanni, Nifosì Riccardo, Albertazzi Lorenzo, Storti Barbara, Bizzarri Ranieri, “Polarity-sensitive coumarins tailored to live cell imaging” Journal of the American Chemical Society 2010, 132, 1276-1288.
  5. Signore Giovanni, Nifosì Riccardo, Albertazzi Lorenzo, Bizzarri Ranieri, “A novel coumarin fluorescent sensor to probe polarity around biomolecules” Journal of Biomedical Nanotechnology 2009, 5, 722-729
  6. Signore Giovanni, Malanga Corrado, Menicagli Rita, “Pyridine and Triphenylphosphine Oxide Activation of Sulfonyl Chlorides in the Syntheses of (E) Alk-1-enyl Sulfones” Tetrahedron, 2008, 64, 11218-11223
  7. Signore Giovanni, Malanga Corrado, Menicagli Rita, “Alkyl alk-1-enyl alanes in Reissert like reaction” Tetrahedron, 2008, 64, 197-203
  8. Signore Giovanni, Calderisi Marco, Malanga, Corrado, Menicagli Rita, “Alkenylalane-pyridine complexes in a new synthesis of aryl alk-1-enyl sulfoxides” Tetrahedron, 2007, 63, 177-182
  9. Signore Giovanni, Samaritani Simona, Malanga Corrado, Menicagli Rita, “Reinheckel Protocol Revisited: Synthesis of (E)-a,b -unsaturated Sulfoxides” Synthesis 2006, 762-764
  10. Dianzani Chiara, Collino Massimo, Gallicchio Margherita, Samaritani Simona, Signore Giovanni, Menicagli Rita, Fantozzi Roberto “Evaluation of in-vitro anti-inflammatory activity of some 2-alkyl-4,6-dimethoxy-1,3,5- triazines” Journal of Pharmacy and Pharmacology 2006, 58, 219-226
  11. Samaritani Simona, Signore Giovanni, Malanga Corrado and Menicagli Rita “Organometallic alkylation of 2-chloro-4,6-dimethoxy-1,3,5-triazine: a study” Tetrahedron 2005, 61, 4475-4483
  12. Menicagli Rita, Samaritani Simona, Signore Giovanni, Vaglini Francesca, Dalla Via Lisa “In Vitro Cytotoxic Activities of 2-Alkyl-4,6-diheteroalkyl- 1,3,5-triazines: New Molecules in Anticancer Research” Journal of Medicinal Chemistry 2004, 47, 4649-4652