Giuseppe Bardi's foto

Giuseppe Bardi

Senior Post Doc

IIT@NEST

Address Piazza San Silvestro,12
City Pisa
State/Region Tuscany
ZIP Code 56127
Country Italy
Phone +39 050 509736
Fax +39 050 509417

Bio

Giuseppe Bardi graduated (cum laude) in Cellular and Molecular Biology at University of Bologna (Italy). The result obtained during his thesis in Cellular Neurobiology where published in the Journal of Neurochemistry (1998 Nov;71(5):1898-904).

In 2001 he received the PhD at The Theodor Kocher Institute in Bern (Switzerland) discussing a thesis on Chemokine Receptors’ internalization under the supervision of Prof Marco Baggiolini.

Giuseppe followed investigation on immune cell signaling at The Babraham Institute (Cambridge, UK) and Temple University (Philadelphia, PA, USA), before working as Research Associate in the Dep. Of Pharmacology and Physiology, College of Medicine at Drexel U. (Philadelphia, PA, USA).

Back to Italy in 2006, he focused his attention on engineered nanoparticles interaction with primary neurons at the Neuroscience Institute CNR (Pisa, Italy).

On February 1st 2011, Giuseppe joined the Center for Nanotechnology Innovation @ NEST (Istituto Italiano di Tecnologia), where he is responsible for the research in nanotoxicology and ENM-induced immune reactions.

 

Other Publications

Publication list (® Corresponding Author; ^ Equal Contribution)

 

Raffa V, Gherardini L, Vittorio O, Bardi G, Ziaei A,Pizzorusso T,Riggio C, Nitodas S,mKarachalios T,Al-Jamal K, Costa M, Cuschieri A. CNT-mediated wireless cell permeabilisation: drug and gene uptake. Nanomedicine (Lond). 2011 Dec;6(10):1709-18. PubMed PMID: 22122583

Ceccatelli S, Bardi G©. Neurologic Diseases, Adverse Effects of Engineered Nanomaterials, Elsevier (invited book chapter)

Bardi G©. SiO2 NPs: Promising Candidates for Drug and Gene Delivery. . Drug Delivery Letters. 2011 1, 9-12

Bardi G©. Carbon nanotubes and neurons: biocompatibility concerns. J.Nanosci.Lett. 2011 Oct (3) 166-171 (available online on May 14 2011)

Bardi G©. Safety of carbon nanotubes for neuronal tissue. Nanomedicine and the nervous system, Nanoscience Applied to Health and Medicine (book chapter, in press)

Al-Jamal KT^, Gherardini L^, Bardi G^, Nunes A, Guo C, Bussy C, Herrero MA, Bianco A, Prato M, Kostarelos K, Pizzorusso T. Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing. Proc Natl Acad Sci U S A. 2011 Jun 20. [Epub ahead of print] PubMed PMID: 21690348.

Song C, Rahim RT, Davey PC, Bednar F, Bardi G, Zhang L, Zhang N, Oppenheim JJ, Rogers TJ. Protein Kinase C{zeta} Mediates {micro}-Opioid Receptor-induced Cross-desensitization of Chemokine Receptor CCR5. J Biol Chem. 2011 Jun 10;286(23):20354-65. Epub 2011 Mar 18. PubMed PMID: 21454526.

Bardi G©, Malvindi MA, Gherardini L, Costa M, Pompa PP, Cingolani R, Pizzorusso T. The biocompatibility of amino functionalized CdSe/ZnS quantum-dot-Doped SiO2 nanoparticles with primary neural cells and their gene carrying performance. Biomaterials. 2010 Sep;31(25):6555-66. PubMed PMID: 20537383.

Ciofani G, Raffa V, Vittorio O, Cuschieri A, Pizzorusso T, Costa M, Bardi G. In vitro and in vivo biocompatibility testing of functionalized carbon nanotubes. Methods Mol Biol. 2010;625:67-83. PubMed PMID: 20422382.

Maffei M©, Funicello M, Vottari T, Gamucci O, Costa M, Lisi S, Viegi A, Ciampi O, Bardi G©, Vitti P, Pinchera A, Santini F. The obesity and inflammatory marker haptoglobin attracts monocytes via interaction with chemokine (C-C motif) receptor 2 (CCR2). BMC Biol. 2009 Dec 17;7:87. PubMed PMID: 20017911; PubMed Central PMCID: PMC2809058.

Bardi G©, Vittorio O, Maffei M, Pizzorusso T, Costa M. Adipocytes differentiation in the presence of Pluronic F127-coated carbon nanotubes. Nanomedicine. 2009 Dec;5(4):378-81. Epub 2009 Feb 13. PubMed PMID: 19523412.

Bardi G©, Tognini P, Ciofani G, Raffa V, Costa M, Pizzorusso T. Pluronic-coated carbon nanotubes do not induce degeneration of cortical neurons in vivo and in vitro. Nanomedicine. 2009 Mar;5(1):96-104. Epub 2008 Aug 8. PubMed PMID: 18693142.

Finley MJ, Chen X, Bardi G, Davey P, Geller EB, Zhang L, Adler MW, Rogers TJ. Bi-directional heterologous desensitization between the major HIV-1 co-receptor CXCR4 and the kappa-opioid receptor. J Neuroimmunol. 2008 Jul 15;197(2):114-23. Epub 2008 Jun 3. PubMed PMID: 18533278; PubMed Central PMCID: PMC2596309.

Bardi G, Sengupta R, Khan MZ, Patel JP, Meucci O. Human immunodeficiency virus gp120-induced apoptosis of human neuroblastoma cells in the absence of CXCR4 internalization. J Neurovirol. 2006 Jun;12(3):211-8. PubMed PMID: 16877302; PubMed Central PMCID: PMC2665038.

Patel JP, Sengupta R, Bardi G, Khan MZ, Mullen-Przeworski A, Meucci O. Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO. J Neurovirol. 2006 Dec;12(6):492-500. PubMed PMID: 17162664; PubMed Central PMCID: PMC2676683.

Vigorito E, Bardi G, Glassford J, Lam EW, Clayton E, Turner M. Vav-dependent and vav-independent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus. J Immunol. 2004 Sep 1;173(5):3209-14. PubMed PMID: 15322182.

Bardi G, Niggli V, Loetscher P. Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes. FEBS Lett. 2003 May 8;542(1-3):79-83. PubMed PMID: 12729902.

Clayton E, Bardi G, Bell SE, Chantry D, Downes CP, Gray A, Humphries LA, Rawlings D, Reynolds H, Vigorito E, Turner M. A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med. 2002 Sep 16;196(6):753-63. PubMed PMID: 12235209; PubMed Central PMCID: PMC2194055.

Bardi G, Lipp M, Baggiolini M, Loetscher P. The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC. Eur J Immunol. 2001 Nov; 31(11):3291-7. PubMed PMID: 11745346.

Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M. Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5. Blood. 2001 Apr 1; 97(7):1920-4. PubMed PMID: 11264152.

Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I. The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. J Biol Chem. 2001 Feb 2; 276(5):2986-91. Epub 2000 Nov 10. PubMed PMID: 11110785.

Sparapani M, Virgili M, Bardi G, Tregnago M, Monti B, Bentivogli M, Contestabile A. Ornithine decarboxylase activity during development of cerebellar granule neurons. J Neurochem. 1998 Nov;71(5):1898-904. PubMed PMID: 9798913.

Projects

Giuseppe's main research focuses:

  • Drug/gene delivery nano-carrier interaction with neural cells and activation of microglia
  • Blood Immune Cells' activation induced by nanoparticles