Dynamics and Interactions of Membrane Receptors in Living Cells

Laura Marchetti is a post-doc researcher with a solid background in molecular and cellular biology and a strong attitude to interdisciplinary approaches. She is currently working at the interface between biophysics and cellular biology, by applying single-molecule fluorescence imaging approaches to investigate the membrane and intracellular dynamics of neurotrophins and their receptors.

She has contributed to the development of means to:

i) evaluate the changes of receptor membrane mobility induced by ligand binding in living cells;

ii) label both neurotrophins and their receptors with controlled stoichiometry and with fluorophores suitable for single-molecule imaging purposes;

iii) control the expression level of recombinant proteins expressed in mammalian cells using lentiviral vectors and inducible promoters.

These molecular tools were and are still being used in a number of different projects that allowed her to collaborate with different research groups (NEST and BioSNS Labs of Scuola Normale Superiore in Pisa, EBRI Institute in Rome, Department of Molecular and Translational Medicine of Brescia Univeristy) and supervise the activity of several MSc and PhD students.

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