From Nov 2010 Post-Doctoral position at Italian Institute of Tecnology, IIT@NEST- Center for Nanotechnology Innovation, Pisa, Italy.
2006-2010 Research position at Institute of Clinical Physiology, CNR – Pisa, Italy. Project: Markers/targets identification & validation and biological pathway assessment through proteomic and Mass Spectrometry investigation in cardiovascular diseases.
2008 Degree in Drug Quality Control (106/110), University of Pisa, Italy.
2007 PhD in Medical Pathophysiology and Pharmacology. University of Pisa, Italy. Project: A Proteomic approach for the identification of early markers of Vascular Smooth Muscle Cells (VSMC) activation
2003 Degree in Pharmaceutical Chemistry and Technology (110/110). University of Pisa, Italy.
My research interest lies within the study of complex molecular systems for diagnostics and therapeutics in cells and in vivo. In particular in the development of new modular systems, able to perform efficiently channeling, selective targeting, imaging, and controlled release of appropriate payloads. This means:
- peptide solid-phase chemical synthesis;
- purification of synthetic peptides and mass spectrometry characterization;
- chemical functionalization and labeling of the developed sequences with fluorescent or magnetic probes;
C. Boccardi, A. Cecchettini, A. Caselli, Camici, M. Evangelista, A. Mercatanti, G. Rainaldi, L. Citti, “A proteomic approach to the investigation of early events involved in Vascular Smooth Muscle Cell activation” Cell and Tissue Research 2007 Jule;329(1):119-28.
G. M. Ghiggeri, M. Bruschi, L. Musante, G. Candiano, C. Boccardi, L. Citti, M. P. Rastaldi, S. Mangraviti, G. Rosso, A. Larti, A. Rosati, A. Urbani, R. Gusmano, E. Bertoni, M. Salvatori “Post-transplant proteinuria associated with everolimus: Definition of main features with proteomics” Proteomics - Clinical Application 2008 Sept, 2:1327-37.
E. Bretoni, M. Bruschi, G. Candiano, C. Boccardi, L. Citti, S. Mangraviti, G. Rosso, A. Larti, A. Rosati, G. M. Ghiggeri, M. Salvadori “Post-transplant proteinuria associated with everolimus” Trasnplantation Proceedings 2009 May, 42: 1216-1217
S. Rocchiccioli, L. Citti, C. Boccardi, N.Ucciferri, L. Tedeschi, C. Lande, M. G. Trivella and A. Cecchettini “A gel-free approach in vascular smooth muscle cell proteome: perspectives for a better insight into activation” Proteome Science 2010 Mar 24;8:15.
S. Rocchiccioli, E. Congiu, C. Boccardi, L. Citti, A. Laganà, E. Capobianco “A proteomic study of microgravity cardiac effects: feature maps of label-free LC-MALDI data for differential expression analysis” Mol Biosyst. 2010 Nov;6(11):2218-29. Epub 2010 Aug 31.
A. Cecchettini, S. Rocchiccioli, C. Boccardi, L. Citti “Vascular smooth-muscle-cell activation: proteomics point of view” Int Rev Cell Mol Biol. 2011;288:43-99.
L. Citti, S. Rocchiccioli, A. Mercatanti, C. Boccardi, O. Parodi, International Patent: “Method for separating the constituents of a complex mixture of proteins to submit to proteomic analysis and apparatus therefor” Applicazione Internazionale.” PCT/IB2009006989