Our efforts are devoted to the translation of noble metal nanomaterials to the bed-side by addressing the issue of metal persistence, in order to promote innovative and non-invasive treatments for neoplasms and infectious diseases.
By employing the ultrasmall-in-nano design, we have developed the passion fruit-like nano-architectures (WO2016/139591): an all-in-one inorganic nanomaterial able to jointly combine most of the intriguing behaviors of noble metal nanoparticles with their excretion from organism. Our main interests are related to photothermal conversion, drug delivery, photoacoustic/ultrasound imaging. In agreement with the 3R concept, we also continuously develop new 3D cancer models to test nanomaterials.
Thanks to the support of Fondazione AIRC we are especially working on combined treatments for head/neck neoplasms.
We are also involved in the development of novel nanorattle catalysts for hydrogen storage and automotive exhaust gas treatment.
Translatable NanoTheranostics
Group members
Publications
2023
Ermini M.L., Summa M., Zamborlin A., Frusca V., Mapanao A.K., Mugnaioli E., Bertorelli R., Voliani V.
Copper nano-architecture topical cream for the accelerated recovery of burnt skin
Nanoscale Advances, vol. 5, (no. 4), pp. 1212-1219
2023
Zamborlin A., Voliani V.
Gold nanoparticles as antiangiogenic and antimetastatic agents
Drug Discovery Today, vol. 28, (no. 2)
2023
Sarogni P., Zamborlin A., Mapanao A.K., Logghe T., Brancato L., van van Zwol E., Menicagli M., Giannini N., Gonnelli A., Linsalata S., Colenbier R., Van den Bossche J., Paiar F., Bogers J., Voliani V.
Hyperthermia Reduces Irradiation-Induced Tumor Repopulation in an In Vivo Pancreatic Carcinoma Model
Advanced Biology
2022
Che P.P., Mapanao A.K., Gregori A., Ermini M.L., Zamborlin A., Capula M., Ngadimin D., Slotman B.J., Voliani V., Sminia P., Giovannetti E.
Biodegradable Ultrasmall-In-Nano Architectures Loaded with Cisplatin Prodrug in Combination with Ionizing Radiation Induces DNA Damage and Apoptosis in Pancreatic Ductal Adenocarcinoma
Cancers, vol. 14, (no. 12)
2022
Sarogni P., Mapanao A.K., Gonnelli A., Ermini M.L., Marchetti S., Kusmic C., Paiar F., Voliani V.
Chorioallantoic membrane tumor models highlight the effects of cisplatin compounds in oral carcinoma treatment
iScience, vol. 25, (no. 3)
Collaborations
- Prof. Gang Zheng, Princess Margaret Cancer Centre and TECHNA Institute (Toronto, CA)
- Prof. Hélder Santos, University of Helsinki (Helsinki, FI)
- Prof. Maksym Pogorielov, Medical Institute - Sumy State University (Sumy, UA)
- Prof. Fabiola Paiar, Radiation Oncology - Pisa University Hospital (Pisa, IT)
- Prof. Emanuele Neri, Department of Translational Research - University of Pisa (Pisa, IT)
- Prof. Elisa Giovannetti, Department of Medical Oncology - Amsterdam University Medical Center (Amsterdam, NL)
- Prof. Luca Menichetti, IFC-CNR (Pisa, IT)
- Prof. Fabio Marchetti, Department of Chemistry and Industrial Chemistry - University of Pisa (Pisa, IT)
- Prof. Alex Tovstolytkin, Institute of Magnetism - National Academy of Sciences of Ukraine (Kyiv, UA)
- Dr. Rosalia Bertorelli, In vivo Facility - Istituto Italiano di Tecnologia (Genoa, IT)
- Dr. Laura Poliseno, Oncogenomics Unit - Core Research Laboratory - CNR (Pisa, IT)
- Dr. Orazio Vittorio, Children's Cancer Institute (Sydney, AU)
- Dr. Giuseppe Cirillo, Università della Calabria (Cosenza, IT)
Journal covers
